Technician position

The Functional Cancer Genomics group directed by Prof. J.P. Theurillat at the Institute of
Oncology Research in Bellinzona, Switzerland is seeking a Technician.

The Functional Cancer Genomics group directed by Prof. J.P. Theurillat at the Institute of
Oncology Research in Bellinzona, Switzerland (www.ior.iosi.ch) is seeking a part- or
full-time technician in cancer research.
The successful candidate will work as part of an international team that is dedicated to
understanding how new driver alterations culled from cancer genome characterization studies
promote tumorigenesis, and how gathered insights can be exploited to develop precision
medicines. The position offers excellent scientific opportunities in a highly stimulating and
interdisciplinary environment involving close interactions between medical and basic
scientists. Investigations range from projects related to:

• Patient-derived xenograft (PDX) mouse models to study the biology of prostate
  cancer


• Determining anti-tumor activity of novel drug-like compounds in vivo

Candidate requirements

• Working experience with mouse models (tumor xenograft models or genetically-
  engineered mice): breeding setup and grafting of tumors, drug application, small
  surgery (castration), tissue preservation


• Working experience in cell culture models and basic molecular biology desirable


• MSc in biology

The position is located at the Institute of Oncology Research, a leading institution in basic and
translational cancer research in Southern Switzerland with state-of-the-art core facilities and
competitive salaries. The highly collaborative lab has ongoing projects with groups at Harvard,
MIT and ETHZ, among others.
Position available immediately.
Applicants should submit curriculum vitae, cover letter and contact info for 2 references to
jean-philippe.theurillat@ior.usi.ch with reference JPT_Technician2021 .
For additional inquiry regarding this job please contact Prof. Jean-Philippe Theurillat via email:
jean-philippe.theurillat@ior.usi.ch.
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Selected recent publications:

• Janouskova H, et al. Opposing effects of cancer type-specific SPOP mutations on
  BET protein degradation and sensitivity to BET inhibitors. Nat Med 2017. PMID:
  28805821


• Groner A, et al. TRIM24 is an oncogenic transcriptional activator in prostate cancer.
  Cancer Cell 2016 PMID: 27238081


• Theurillat JP, et al. Ubiquitylome analysis identifies dysregulation of effector
  substrates in SPOP-mutant prostate cancer. Science 2014 PMID: 25278611


• Whittaker SR, et al. A genome-scale RNA interference screen implicates NF1 loss in
  resistance to RAF inhibition. Cancer Discov 2013 PMID: 23288408


• Barbieri CE1, et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12
  mutations in prostate cancer. Nat Genet 2012 PMID: 22610119


• Theurillat JP, et al. URI is an oncogene amplified in ovarian cancer cells and is
  required for their survival. Cancer Cell 2011 PMID: 21397856