Job Detail

(2 years temporary contract, starting April 2020 or upon availability, full time)

The Investigative Safety department is a well-established and respected group of 80 people responsible for the conduct of all in vitro work to determine the preclinical ADME and safety of new Roche medicines. We are seeking a highly motivated associate, dedicated to the development and application of advanced human cellular models of the tumor microenvironment with a strong focus on the vasculature.

 Who you are:

• 2+ years of experience in a research lab and a MSc or BSc in a related scientific field, lab associate or similar education.

• You are a motivated research assistant with excellent scientific, communication and organizational skills, fully committed to team effort but able to work independently.

• A strong background in sterile cell culture is essential, ideally with experience in organoid cultures and primary cell handling

• You have experience in designing, executing and troubleshooting multi-color flow cytometry

• You are expert in cell biology, ideally with a background in tumor microenvironment

• The ideal candidate should possess scientific and intellectual curiosity, and be willing to learn and apply innovative research tools, including advanced 3D culture models such as organoids and micro-physiological systems.

• Familiarity with standard lab equipment and data analysis software (e.g. Microsoft Office, Excel macros, Prism or similar, electronic lab book) is desired

Responsibilities:

• Be responsible for the design and execution of experimental work, and conduct data analysis and documentation

• Isolation, characterization and banking of cells and organoids from fresh healthy and diseased human tissue

• Perform routine lab work including passaging and maintenance of primary cells and organoids

• Assist with development and application of advanced in vitro micro physiological models of the tumor microenvironment

• Routinely perform multi-color flow cytometry experiments and multiplex cytokine analysis, as well as fluorescent immunostaining and imaging.

• Collaborate with associates in other groups for advanced sample preparation (Multi-Omics, 3D-imaging, histopathology, high content imaging …)