200+ projects in clinical development. That’s what’s keeping us busy. At the Biologics Center (NBC) at Novartis Institutes for BioMedical Research (NIBR), we are studying the Adeno-associated virus (AAV) which is a very attractive modality for gene therapy.
We are seeking a highly motivated scientist with expertise in AAV gene therapies interested in joining a dynamic and experienced cell and gene therapy team at Novartis to push new frontiers in targeted vector design and gen(om)e editing aiming for one-time curative therapy using edited hematopoietic stem cells for sickle cell disease and HIV. Working together with the Bill & Melinda Gates Foundation (BMGF), we will bring these innovative treatments to the people across the work who need it most (www.novartis.com/news/media-releases/novartis-and-bill-melinda-gates-foundation-collaborate-discover-and-develop-accessible-vivo-gene-therapy-sickle-cell-disease ). This position resides in the Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC in Basel, Switzerland. The BEGT group drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics, AAV and lentiviral vectors. The BEGT group works collaboratively with Disease area groups to broaden the use of biologics in therapeutic applications where conventional antibodies have limitations. This role will be offered for a duration of three years.
Your responsibilities will include, but not limited to:
• Designing and generating novel viral constructs that address challenges in the field of gene therapy;
• Applying expertise in protein engineering to improve functionality of novel AAV modalities;
• Collaborate with and support discovery unit to select and screen for desired targeting molecules using Phage and/or Yeast Display;
• Presenting experimental design, protocols, results and interpretations in lab group and project team meetings;
• Partnering with project teams in decision making to agree on desired deliverables and timelines;
• Maintaining familiarity with current scientific literature and techniques in the field of gene therapy.
What Novartis can offer you?
• Work with the latest technologies
• Opportunity to work on the Adeno-associated virus (AAV), very attractive candidate for creating viral vectors for gene therapy
• Be part of a world class organization dedicated to providing solutions to un-met medical needs
• Join an organization that is committed to your development and advancement
Minimum requirements
What you will bring to the role:
• Recent PhD with not more than 2 years’ experience or BS/MS with minimum of 10+ years’ experience in virology, molecular biology, biochemistry, genetics or a related field;
• Experience in design, production and characterization of adeno-associated virus;
• Experience in Capsid engineering for improved target tissue specificity;
• Expertise in library generation and screening/selection approaches like Phage or Yeast display to identify binding molecules against desired targets;
• Excellent oral and written communication and interpersonal skills;
• Self-motivation, enthusiasm, and scientific curiosity.
799 million. That’s how many lives our products touched in 2019. And while we’re proud of that, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?
We believe the answers are found when curious, courageous and collaborative people like you are empowered to ask new questions, make bolder decisions and take smarter risks.
We are Novartis. Join us and help reimagine medicine. Division NIBR Business Unit BIOTHERAPEUTIC AND ANALYTICAL TECHNOLOGIES - NIBR Location Switzerland Site Basel Company/Legal Entity Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Temporary Shift Work No
