Vacancy details

General information

Reference

Information about Molecular Partners AG

Founded in 2004 by a group of PhD students as a spin-off from the University of Zurich, Molecular Partners AG is a thriving and steadily growing clinical stage biotech company located in Zurich-Schlieren (Switzerland) with 160 highly qualified employees.

In order to advance modern medicine and significantly improve the management of serious diseases, we have developed and successfully established a powerful new class of potent, specific and versatile small protein therapies, called DARPin® therapeutics.

The continuous development of a broad portfolio of therapeutic product candidates in oncology and ophthalmology based on the company’s proprietary DARPin® platform allowed a successful listing of the company on the SIX Swiss Exchange (ticker: MOLN). Next to our own pipeline of drug candidates we have entered into collaborations with leading international pharmaceutical companies, including Abbvie, Amgen, Novartis, Roche and Janssen Pharmaceuticals.

The highly dedicated, multi-disciplined team at MP is committed to developing breakthrough medicines for serious diseases.

Position description

Position title

Head, In-vivo Immune-Oncology (100%) M/F

Job description

We are developing a strong portfolio of assets in immune-oncology and other indications with a focus on novel concepts based upon our versatile DARPin technology. Analysis of these DARPin molecules in in-vivo models is a key component and central for the progress of projects. We are looking for a motivated and highly experienced leader of our in-vivo team responsible for all internal and external in-vivo studies. This challenging and diverse position will include the following tasks and responsibilities:

• Lead a team that provides highest quality internal and external in-vivo efficacy, pharmacodynamic, pharmacokinetic and bio distribution studies as well as mouse related ex-vivo analysis for our pipeline projects.


• Ensure that deep content expertise is built and maintained


• Ensure scientific rigor and quality of data


• Ensure highly effective execution of work


• Ensure highly effective collaboration of members within the team as wells as cross-functional collaboration within project teams


• Ensure organization and maintenance of highly functional mouse in-vivo facility including implementation of state-of-the-art technologies (e.g. micro sampling, non-invasive monitoring, …)


• Ensure building and maintenance quality CRO network to complement in-house activities


• Ensure high quality documentation of internal and external studies

Requirements

For this challenging position, we are looking for a highly motivated individual with a Ph.D. in biology, immunology or a related discipline, or an equivalent qualification, with a minimum 10 years of relevant experience in pharmaceutical industry drug discovery and development with a focus on in-vivo efficacy, pharmacology and PK/PD studies. You should further bring along:

• Experience and deep understanding of in-vivo mouse models (e.g. syngeneic, humanized and transgenic mouse model), ideally oncology and immune-oncology, for the characterization of therapeutics


• Scientific understanding of immunology, oncology, biology, biomarker and translatability between experimental models and human patients


• In addition to pharmacodynamical model experience, demonstrate understanding of pharmacokinetics, imaging systems and ex vivo analysis such as immunophenotyping by flow cytometry, immunohistochemistry, cytokine analysis and -omics methodologies


• Strong experience working in a cross-functional organization


• Good understanding of protein therapeutic development


• Excellent team leadership and management skill


• Ability to plan and communicate complex studies in a fast-paced environment


• Sound oral and written English is a must

   

Our offer

Partnership and collaboration are at the core of our company, our research activities and our product candidates. Molecular Partners offers an international working environment and the opportunity to collaborate with outstanding individuals from numerous disciplines, who contribute to our shared goals of scientific excellence, respectful teamwork and personal aspiration.

We foster true innovation and creative thinking to advance our therapeutic product candidates and continue to be inspired by the difference we can make for our patients.

At Molecular Partners you will discover a challenging job, inspiring colleagues and a true purpose. If you are interested in working at Molecular Partners, we are looking forward to hearing from you! Please submit your detailed curriculum vitae via our career portal.

We only accept online applications.

Position localisation

Job location

Switzerland, Zürich, Schlieren

Preferred head hunter clause

Please note Molecular Partners AG operates a list of preferred recruitment partners. For those partners who have no valid, signed agreement in place with Molecular Partners AG, all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Molecular Partners AG (including any of its subsidiaries, affiliates or related companies) are not subject to payment of any form of introduction, placement or referral fees.