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Two Master thesis positions in leukemic stem cells & myeloid leukemia research 100% - 100% | befristet

Inseriert am: 04.11.2020

Two Master thesis positions in leukemic stem cells & myeloid leukemia research


The laboratory of "Stem Cells, Leukemia, Aging and Metabolism (SLAM)" at the University Clinic of Hematology & Central Hematology, Department for BioMedical Research (DBMR), Inselspital Bern, Switzerland is looking for highly motivated master students to contribute to the ongoing multidisciplinary research projects in leukemia. The major focus of the lab is to explore leukemic stem cell dependencies and vulnerabilities using transgenic mouse models and primary patient samples from leukemia patients.

Your ProfileHighly motivated Master's students with a strong passion towards fundamental and translational cancer research. Any relevant hands on laboratory experience will be a plus but not obligatory.We offer youThe student will be guided through an interdisciplinary and clearly defined research project in a young and dynamic environment. The proposed project will investigate the therapeutic relevance of targeting selected altered metabolic pathways in myeloid leukemias and other hematological cancers by using:

• In vitro techniques such as cloning, CRISPR/Cas9 genome editing, stem cell cultures, pharmacological inhibitors, metabolic flux analysis, RT-qPCR and flow cytometry.

• Transgenic mouse models of myeloid leukemia. ApplicationPlease submit your application in a single Pdf file including cover letter (one page max) specifying your research interests and why you are interested in joining our lab, CV (two pages max) and copies of Bachelor and/or Master's degree to: tata.nageswararao@dbmr.unibe.ch with desired start date!!!

Successful applicants will get a unique opportunity to participate in a highly translational project, as well as to master cutting edge molecular and cell biology techniques. The duration of master thesis is 6-12 months. The starting date is negotiable.Further reading1). Rao TN et al., Metabolic alterations in JAK2 mutant hematopoietic cells represent therapeutic vulnerabilities for myeloproliferative neoplasms. Blood. 2019.

2). Rao TN et al., Attenuation of PKC activity enhances metabolic activity and regenerative capacity of blood progenitors. The EMBO Journal, 2018.



Further inquiries

Dr. Tata Nageswara Rao, PhD (Group leader)

Stem Cells, Leukemia, Aging and Metabolism (SLAM) laboratory


www.unibe.ch

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