Job Detail

The position:

We are offering a Research Associate position in our Roche Innovation Center in Basel.

This position is sponsored by the Center of Excellence in Human Translational Bioengineering. The center conducts dedicated research focused on organoids, organs on a chip, other promising human translational models, and the use of synthetic biology and genome editing to advance human model systems, in order to advance our ability to develop new medicines with greater predictability. One of the key aims is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals, if necessary preceded by priority patent applications.

As a Research Associate you will focus on an exploratory research project titled 'Elucidating the molecular pathophysiology in neuro-degeneration in human cerebral organoids (3D) models in Alzheimer’s disease (AD) and Parkinson's disease (PD)'.

In this position, you will:

• Perform genome editing of risk genes of Alzheimer and Parkinson disease in human pluripotent stem cells to model Alzheimer and Parkinson disease


• Establish and characterize 3D human cerebral organoids models of an Alzheimer’s disease and a Parkinson’s disease risk gene by developing state of the art standardized operating protocols


• Seek to identify the normal physiological function of these risk genes and the pathways impacted by the disease associated mutations in individual cell types

Who are we looking for?

You are an experienced professional in the field of cell biology or molecular biology. You have 6+ years of experience after an apprenticeship or 3+ years of experience with a Master degree. And you have experience and expertise in the following:

• Cell culture of human cell lines, pluripotent stem cells and primary cells


• Molecular biology with experience in Genome editing is a plus


• Advantage is if you have experience in hiPSC derived 2D neuronal models and hiPSC derived brain-region specific organoids

You have very good interpersonal and communication skills, are able to build good working relationships, and are an outstanding teammate. Your experience and investigative attitude allow you to work independently, to design, perform, and interpret experiments, and to embark on new scientific methodologies.

Application process:

Please note that profiles holding a PhD do not qualify for this opportunity.

All applications shall include a CV, a motivation letter, a publication list (if available) and list of referees and, if available, your degrees. Please clearly indicate your preferred starting date on your motivation letter.

Do you know what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq

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Roche is an equal opportunity employer.

Research & Development, Research & Development > Research