Molecular Cell Biology Research Assistant

100% - Ref.: IOB048

The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated Research Assistant to join the Translational Group working in close collaboration with the IOB Retinal Organoid Platform.
The main goal of the Translational Group is to develop and bring new classes of therapies to the clinic. We specifically focus on gene therapy and base editing technologies to provide treatments for genetic vision loss. Our activities include developing gene editing assays, performing proof-of-concept studies in cells, organoids, retinal explants and animal models, optimizing lead candidate therapeutic agents, perform safety and biodistribution studies, characterize and recruit patients for the clinical trials, develop clinical outcome measures and prepare for regulatory authorization. The Translational Group is an interdisciplinary environment and acts as a bridge between IOB's Molecular and Clinical Center to allow rapid translation of scientific results into therapy.
IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding vision and its diseases and develop new therapies for vision loss. It is a place where your expertise will be valued, your abilities challenged, and your knowledge expanded.

Your position

• In vitro culture of human pluripotent stem cells and derivation of retinal organoids


• Genome engineering of pluripotent stem cells by CRISPR/Cas9


• Vector construction and molecular cloning


• Analysis of retinal organoids by various histology and microscopy techniques


• Developing assays for gene correction in organoid models of disease


• Performing proof-of-concept gene correction experiments on organoid models


• Involvement in lab management and organization


• Involvement in the translation of cutting-edge precision gene therapies and close collaboration with group members and IOB groups

Your profile

• Biologielaborant/in (or equivalent education) or Bachelor's/Master's Degree (or equivalent) in molecular biology or related field


• Minimum 3 years of full-time working experience in research


• Extensive experience with cell culture


• Willingness to work with human tissue and standard hazardous laboratory compounds


• Highly organized, detail-oriented and skilled with computers


• Good written and verbal communications skills


• Willingness to work during some weekends and public holidays


• Fluency in oral and written English

We offer you

• Highly competitive conditions in a dynamic and international research community in Basel


• IOB is an equal-opportunity employer with family-friendly work policies

Application / Contact

nterested candidates should submit their application documents as a single PDF file to jobs@iob.ch by May 15th, 2020. Please indicate the position you are applying for by writing the reference number (IOB048) on the subject line.

For further information, please visit our website
www.iob.ch or contact Dr. Bence Gyorgy at bence.gyoergy@iob.ch (no application documents to this email).

www.unibas.ch