Job Detail

Polyphor is a clinical stage biopharmaceutical company based in Allschwil, Switzerland, and is
focused on the discovery and development of antibiotics and other specialty pharma products for
severe or life-threatening diseases. We are currently looking for a:

10065 Senior Scientist / Pharmacologist in Oncology
Responsibilities:

• Project management of a drug discovery project


• Design and supervision of in vivo and in vitro studies at CROs and academic partners to
  support project advancement as necessary


• Establish complex PK/PD/efficacy models to generate supportive data for drug
  combinations and for specific cancer sub-indications


• Selection of ex vivo assays to broaden the understanding of the MoA in the tumor
  microenvironment, immune surveillance, angiogenesis and tumor growth control


• Translational science and exploratory biomarker work at clinical sites


• Management and supervision of preclinical study progress at CROs and academic
  partners. Discussion of study documentation, analysis and interpretation


• Written and verbal presentation within a multidisciplinary team environment

Qualifications:

• PhD is required in immunology, oncology, pharmacology or related life sciences


• A minimum of 10 years industry experience with in vivo models selection and evaluation,
  standardization of models, design of PK/PD studies; hands-on expertise in cancer models
  is a plus


• Animal handling skills and hands-on in vivo pharmacology skills, including cell line work,
  preparation of test compounds, dosing, blood and tissue collection for PK and PD
  biomarker analysis


• Experience in preclinical and translational cancer pharmacology and/or pathology


• Knowledge about marker and pathway assessment, e.g. Nanostring, Simoa, other RNA
  and protein-based technologies and genomic approaches


• Basic knowledge about clinical operations is required, more is a plus


• Good scientific and business negotiation skills in discussions with external parties


• Sound and demonstrated project management skills

We are looking for an independent, self-confident person preferably with a well-established KOL
network in preclinical and translational oncology. The ideal candidate is also used to guide a
multidisciplinary project team and is able to manage timelines and priorities appropriately.

The position will be based in our Allschwil offices. Ideal start would be as soon as possible.

Please send your full application documents to the following address: hr@polyphor.com. Direct
applications are preferred. For further information about the offered position, please contact:
Franziska Müller (+41 61 567 16 00).