Lab Head Regulated Large Molecules Bioanalytics

Switzerland, Basel-City, Basel Headquarter

defresrutritptzhja

• Job facts

At Roche, over 90,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

The Clinical Pharmacology and Bioanalytical Research and Development department supports the research and development of transformative therapeutics through state of the art Clinical Pharmacology approaches and world leading bioanalytical technologies. This expertise allows us to characterize Pharmacokinetisc and Pharmacodynamics and sources of variability in the relationships between dose, exposure and response for our drugs and thereby to guide selection of the best dose regimens.

Large Molecule Bioanalytics supports research and development of Biologics, Peptides, and LNAs by enabling and understanding exposure and immunogenicity through state of the art technologies and a world leading integrated holistic bioanalytical approach. We develop assays, analyze samples for Pharmacokinetisc, Anti-drug antibodies and soluble targets along the whole value chain, and provide support in the interpretation of data.

We are currently searching for a Lab Head Regulated Large Molecules Bioanalytics to join our Basel-based team.

Responsibilities:

• Supervise and be responsible for a bioanalytical laboratory doing Large Molecule Regulated Bioanalysis


• Guide the technical personnel career and skill development


• Collaborate closely with the assay development team to design highly sensitive and specific methods for the quantification of therapeutic proteins, the detection of anti-drug antibodies and their characterization in biological material for development and marketing which satisfy the project needs and fulfill laboratory standards


• Validate and apply such bioanalytical methods to the analysis of biological samples generated from toxicity studies and clinical studies according to the principles of GLP and GCP


• Transfer bioanalytical methods to other laboratories (CRO), when necessary


• Report methods and results in appropriate form and contribute to integrated summary documents


• Maintain and build up scientific and technical knowledge in the state-of-the-art methodologies for therapeutic protein quantification, anti-drug antibody detection and characterization by particular ligand binding assays and cell-based assays


• Keep awareness in the operation and application of required laboratory equipment


• Take responsibility of adherence to GLP/GCP in his/her area


• Maintain open communication and collaboration with other disciplines within Roche


• Play an active role in the organization of information and expertise sharing, prompt communication and contribution to project coordination


• Consider patent filings and peer-reviewed publications wherever appropriate

Required Training and Qualification:

• You own a University education in Chemistry, Biochemistry, Biology, Pharmacy with master degree, doctoral degree is an additional asset


• You have an experience with leading a laboratory in Regulated BA Large Molecules, in a GLP and GCP environment


• Training in state-of-the-art analytical techniques with proven ability for independent work with special emphasis to ELISAs, cell culture, cell based assays and other molecular based techniques to quantify, qualify and characterize therapeutic proteins and anti-drug antibodies, with computerized data acquisition and with sample preparation techniques


• Good knowledge in English, both written and spoken

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

• Who we areAt Roche, 94,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
  
  Roche is an equal opportunity employer.


• Job facts
  
  
  
  • Location Switzerland, Basel-City, Basel Headquarter
  
  
  • Function Research & Development
  
  
  • Subfunction Pharmacology
  
  
  • Schedule Full time
  
  
  • Job level Individual contributor
  
  
  • Job type Regular
  
  
  • Division Roche Pharmaceuticals
  
  
  • Posted since 2019/01/31
  
  
  • Job-ID 201807-113153
  
  


• Get in touchMr. Mathieu Vetter


• You could also like these jobs

  Roche Postdoctoral Fellowship in Computer-Aided Drug Design (2 years)

  Switzerland, Basel-City, Basel Headquarter

  (Senior) Real World Data Scientist, Neuroscience epidemiologist

  Switzerland, Basel-City, Basel Headquarter

  Lab Head Regulated Large Molecules Bioanalytics

  Switzerland, Basel-City, Basel Headquarter