veröffentlicht am: 21.11.2018
Clinic for Endocrinology, Diabetes & Clinical Nutrition, University Hospital Zurich
Endocrine Research Lab, Department of Endocrinology, Diabetology and Clinical Nutrition at the University Hospital Zurich.
www.endokrinologie.usz.ch/forschung/seiten/endocrine_research_lab.aspx
Our group is working on the elucidation of genetic and functional mechanisms involved in primary aldosteronism and Cushing’s syndrome derived from genome-wide association and sequencing studies from national and European patient registries. Our research program is supported by collaborative grants from the EU, SNF and others. Results have been published in high ranking journals including Nature Genetics, NEJM, Cancer Cells, and Nature Communications.
Main focus of the current project is the in vivo investigation of novel mouse models of steroid hormone excess. These models will be used to evaluate the pathophysiology that results in autonomous secretion of aldosterone and cortisol and its effects on cardiovascular and metabolic endpoints.
100 %
We are seeking highly talented and motivated scientists who will plan and execute experimental research projects in the field of endocrine related hypertension. Eligible candidates for the postdoctoral position should have a solid background with mouse models, genetic and molecular biology techniques, hold a PhD or equivalent doctoral degree, and have a strong motivation and team spirit. They should have the enthusiasm and driving force to bring a scientific question to the utmost end. English skills written and spoken are mandatory. Specifically, the project will involve the following techniques:
- phenotypic analysis of experimental in vivo models from cell-type specific transgenic mice and animals derived from a mutagenesis screen.
- hormone assays and measurements
- morphological analysis and immunohistochemistry
- sequencing analysis (NGS and Sanger sequencing)
- real-time PCR and gene expression analysis
- systemic administration of specific antagonists/agonists
- functional in vitro assays with primary murine and human cells
German, English
Solid expertise in statistical methods and usage of usual office applications.
We offer attractive working conditions in a modern scientific environment with direct links to clinical practice. The Bio-Technopark Zurich/Schlieren harbors numerous university research groups as well as biotech startups. Our department has a strong track record in endocrinology and diabetology and the specific workgroup is highly expertized in the development of novel tumor models for as well as therapeutic strategies against endocrine tumors. The salary is in accordance with the Swiss National Science Foundation guidelines.
For additional information about an employment at the University of Zurich please visit www.pa.uzh.ch/en/Willkommen-an-der-UZH.html
January 2019 (the position is limited to 4 years)
Mrs. Karin Klein
karin.klein@usz.ch
Please include in your application a letter of motivation, CV, certificates and recommendation letters. Please send those to karin.klein@usz.ch
University Hospital Zurich
Division of Endocrinology, Diabetes and clinical Nutrition
Raemistrasse 100
8091 Zurich
31.12.2018